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冠心病患者幽门螺杆菌感染状况相关性研究

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龙源期刊网 http://www.qikan.com.cn 冠心病患者幽门螺杆菌感染状况相关性研究 作者:曲文峰 来源:《中国医药导报》2012 年第 04 期 [摘要] 目的 探讨幽门螺杆菌(helicobacter pylori,Hp)感染与冠状动脉粥样硬化性心脏病 (CHD)二者的关系,进一步了解 Hp 感染在冠心病发病中的作用。 方法 针对 144 例冠心病 患者(冠心病组)和 96 例健康体检者(非冠心病组),用 ELISA 方法检测血清中的抗 HpIgG,采用 Western-blot 方法检测 Hp 感染阳性患者血清中的抗 CagA 抗体,用放射免疫法测定 冠心病组内皮素-1(ET-1),比较合并 Hp 感染的冠心病患者与非 Hp 感染者之间的差异。 结 果 ①冠心病组抗 Hp-IgG 阳性率(60.4%)明显高于非冠心病组(41.7%)(P < 0.05),去除 常见的危险因素后,Hp 感染仍能增加患冠心病的危险性(OR=2.09,95%CI 1.48~3.00)。 ②Hp CagA+毒力亚型感染增加患冠心病的危险性,而 CagA-毒力亚型感染并未明显增加患冠 心病的危险性。③冠心病组 Hp 感染者血浆 ET-1 水*显著高于非 Hp 感染者(P < 0.05)。结 论 Hp 感染是冠心病危险因素,CagA+毒力亚型感染可能更增加患冠心病的危险性,Hp 感染患 者血浆内皮素水*显著升高。 [关键词] 幽门螺杆菌;冠状动脉粥样硬化性心脏病;产细胞毒素相关蛋白 A;内皮素 [中图分类号] R541.5 [文献标识码] A [文章编号] 1673-7210(2012)02(a)-0049-03 Research on the correlation of helicobacter pylori infection in patients with coronary heart disease QU Wenfeng Chengfeng Hospital of Daqing Oilfield General Hospital Group, Heilongjiang Province, Daqing 163411, China [Abstract] Objective To investigate the relationship of helicobacter pylori (Hp) infection and coronary heart disease (CHD), and to know more about the function of Hp infection in invasion of coronary heart disease. Methods The serum Hp-IgG antibodies were measured by ELISA in 144 patients with CHD (CHD group) and 96 healthy persons (non-CHD group). Cytotoxin associated protein A (CagA) antibodies were tested by western-blot assay in patients with Hp infection. Endothelin-1 (ET-1) was tested by RIA. The differences between CHD patients with Hp infection and without Hp infection were compared. Results ①Prevalence of Hp-IgG was higher in CHD group (60.4%) than in non-CHD group (41.7%) (P < 0.05). Removing common risk factors, Hp infection still could increase the danger of CHD (OR=2.09, 95%CI 1.48-3.00). ②Hp CagA+ could increase the danger of CHD, while CagA- didn't increase the danger of CHD obviously. ③In CHD group, the level of ET-1 in patients with Hp infection was higher than that of patients without Hp infection (P < 龙源期刊网 http://www.qikan.com.cn 0.05). Conclusion Hp infection is a risk factor for CHD. CagA+ infection may increase the danger of CHD. The level of ET-1 in patients with Hp infection is improved obviously. [Key words] Helicobacter pylori; Coronary heart disease; Cytotoxin associated protein A; Endothelin 冠心病是严重危害人类健康的常见病,如性别、年龄、高血压、糖尿病、血脂异常、吸 烟、家族遗传性等的冠心病危险因素,一直是人们多年来关注的,但仍有不具备上述因素的冠 心病患者,这说明冠心病的发生可能还有其他原因。Mendall 等在 1994 年初次报道了幽门螺杆 菌(helicobacter pylori,Hp)感染与冠心病的关系,此后还有不少研究者从临床、流行病学及 血清学等方面进行观察研究。本观察研究就 CHD 与 Hp 感染的关系及其发病



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